Relationship of thyroid function with metabolic parameters in euthyroid adults

Objective: Thyroid hormones have a significant effect on carbohydrate, lipid metabolism disorders, and insulin resistance (HOMA-IR) development. Vitamin D (25(OH)D) has been shown also can affect not only the musculoskeletal system, but almost all tissues in body, including thyroid recent years. In study, we aim of this study is to investigate relationship between levels thyroid-stimulating hormone (TSH) within reference range metabolic parameters adults. Methods: 561 adult outpatients were divided into 2 groups low normal (0.27-2.5 mIU/mL) high (2.5-4.2 according TSH, HOMA-IR, 25(OH)D, compared. Results: A statistically positive correlation was found TSH HOMA-IR both group (r = 0.123, p 0.041) 0.196, 0.001). group, with vitamin =-0.200, =0.003), cholesterol =0.143, =0.024), LDL =0.154, =0.018), non-HDL 0.134, 0.035) significant. Conclusion: Our shows that euthyroid adults are related higher lower 25(OH)D levels, interaction major contributor dyslipidemia. explain disorder early stages T2DM. Therefore, believe screening determining optimal target will be beneficial.